First Do No Harm

Aspirin Therapy Revisited

Editor's Note: This will be published at the site shortly, but our newsletter readers always get things first. 

This is something we’ve talked about at this site, but new information from recent studies has forced us to take a closer look at Aspirin Therapy.
 
When Aspirin Therapy first came about, it was aimed simply at keeping platelets from sticking together, or clotting. With the recent revelations that CVD (cardiovascular disease) and most heart attacks are actually the result of inflammation, Aspirin Therapy became even more popular because aspirin is an anti-inflammatory.
 
There is quite a bit of concern over the action of aspirin, acetylsalicylic acid; whether it is the actual chemical makeup that prevents blood from clotting, or whether it’s the ingredient that aspirin is “buffered” with that prevents the clotting.
 
Here is the actual science, put into understandable terms:
 
Aspirin inhibits an enzyme that makes the body synthesize specific prostaglandins that cause inflammation and other prostaglandins that cause platelets to get sticky and form clots. [J. Scientifc Exploration 2000:14(4):623-641]
 
There have been hundreds of studies showing the efficacy of aspirin therapy preventing heart attacks by preventing clotting. Aspirin does not “thin the blood;” it merely prevents clotting.
 
What most of the studies don’t tell you is that the studies used buffered aspirin, and it is now thought that the calcium and magnesium in the buffering pretty much contributed to the positive outcome in all these studies. In fact, the article (above) points out: “Supplemental magnesium and vitamin E have been shown to be more effective than aspirin in lowering heart attack rates as well as overall death rates.”

 
Excuse the digression, but I, like most people, like to bounce around WebMd once in a while to get their take and I discovered this:

NSAIDs reduce inflammation and relieve fever and pain by blocking enzymes and proteins made by the body. NSAIDs such as ibuprofen and naproxen block a protein (called prostaglandin) that makes heavy menstrual bleeding worse. Aspirin does not block this protein." http://www.webmd.com/pain-management/nonsteroidal-anti-inflammatory-drugs-nsaids 

We just published (above): “Aspirin inhibits an enzyme that makes the body synthesize specific prostaglandins that cause inflammation and other prostaglandins that cause platelets to get sticky and form clots. [J. Scientifc Exploration 2000:14(4):623-641]”
 
I left them a note that in 1982, John R. Vane was awarded the Nobel Prize for showing exactly how aspirin inhibits the enzyme cyclooxygenase, preventing the cells of the body from making certain prostaglandins. [Nobel Prize dot Org]  
 
Everyone makes mistakes. Make no mistake about that.
 
Downside to Aspirin Therapy
 
There is a downside to aspirin therapy. Aspirin is classified as a Nonsteroidal anti-inflammatory drug (NSAID). And one thing we know about these drugs today is their continued use leads to CVD (cardiovascular disease) and Heart Attacks (myocardial infarction, or MI).
 
But I’m getting ahead of myself, because you should know that Naproxin and Aspirin are the two safest (as far as CVD is concerned) NSAIDs.
 
However, “Aspirin and NSAID’s reportedly contribute to over 16,000 deaths each year, largely as a result of induced G.I. bleeding.” [EDTA and Chelation Therapy: History and Mechanisms of Action, an Update]
 
Now we should already be aware of the fraud perpetrated upon the public concerning cholesterol and statin drugs. Cholesterol does not cause heart disease; eating saturated fat does not cause heart disease; and taking statin drugs won’t prevent heart attacks. In fact “A meta-analysis of 50 cholesterol-lowering interventions, including diet, resins and lovastatin, lowered cholesterol levels an average of 10%, but there was a 1% increase in overall mortality.” [J. Scientifc Exploration 2000:14(4):623-641]
 
In other words, more people died using the cholesterol lowering drugs than the control group.
 
In fact, here is a flyer advertising Lipitor along with a paragraph “blown up” from the ad. As you can see, Lipitor will not protect you from a heart attack.

  

And get this:

A meta-analysis of trials of calcium channel blockers, even tho they really do lower blood pressure, showed possibly harmful effects overall. In addition, two new antiarrythmia drugs approved by the FDA, encainide and flecainide, clearly suppressed arrythmias, probably as seen by electrocardiograms, as the surrogate endpoint. However, it was found that 3 times as many patients in the drug group died as in the placebo group. [J. Scientifc Exploration 2000:14(4):623-641] 

Because of known problems with aspirin therapy, the recommendation, from conventional medicine and alternative medicine is a smaller dosage. A famous study known as PHS 89 used the magical dosage of 81mg per day with a meal.
 
Were there problems with the study? Well, fewer heart attacks, but more hemorrhagic strokes, and in the end, the people on the aspirin died at the same rate as the control group.
 
In other words, the people on aspirin died from other things, other than heart attacks, so there was no upside to using aspirin.
 
There’s another downside to aspirin that has recently come to light. If you’re going in for surgery, doctors recommended their patients on aspirin therapy quit taking aspirin about a month or so prior to the surgery. After surgery, you’ll want your blood to clot to help heal all that damage the scalpels cause.
 
There was one huge problem noted in these people quitting their aspirin a day therapy: half of them died before the operation. You had a 50% chance of a heart attack before the surgery if you quit taking an aspirin a day.
 
Doctors are now re-thinking this advice, but for brain surgery, you have to be off of your anti-clotting meds because the simplest bleed can kill you.
 
Or, let’s face it; you could always take a little magnesium and a good vitamin E daily.
 
And now the most recent information started coming out about two or three years ago, when a Dr Orr from the Royal College of Surgeons (England) performed a cohort study that went like this:

Software was used to analyze 10,000 patients registered with a large primary care facility who fit the following profile:

  • Over 50 years old.
  • Had been prescribed NSAIDs in the past.
  • Was previously diagnosed with ischemic heart disease, diabetes mellitus and/or hypertension.

And their findings?

  • Heart failure risk was roughly doubled by all NSAIDs.
  • All NSAID regimens increased upper gastrointestinal complications.
  • Major vascular events were increased by about a third by a coxib [Cox-2 inhibitor], chiefly due to an increase in major coronary events.
  • Ibuprofen also significantly increased major coronary events, but not major vascular events.
By “All NSAID regimens” is meant, aspirin too. And this is contrary to the accepted position. Aspirin is supposed to protect against major coronary events. [Aspirin and ibuprofen proven to cause heart attacks]

In England around the turn of the century, they performed an RCT using three groups in what was known as the Wafarin/Aspirin Study in Heart Failure (WASH). Each of the 279 subjects had experienced either a heart attack or a stroke brought on by thrombosis (a blood clot).

As we said, they were divided into three groups: one got a standard dose of Wafarin, one got 300 mg of aspirin, and the third group got a placebo.

Over two years later, follow up uncovered that neither the aspirin nor the wafarin provided any greater protection against nonfatal strokes, nonfatal heart attacks, or death than the placebo. And in the group taking aspirin, they were twice as likely to to suffer a heart attack or stroke as those who took wafarin (or the placebo). And then there are the usual gastrointestinal problems associated with aspirin prompting Dr John G F Cleland, the lead researcher in the study to proclaim that theoretical benefits of aspirin be damned, because the real evidence points to it just doing harm.
 
Now Hear This
 
Most recently this has come to light: If you have an upper respiratory infection, such as a cold or flu, taking aspirin therapy could bloody kill you.
 
Yes, taking an aspirin or any NSAID when you have a cold (or upper respiratory infection such as the flu) triples your risk of a heart attack. And it’s even higher (seven times higher than with no cold or flu) if the painkiller is taken intravenously.
 
The study, first published in the Journal of Infectious Diseases, was conducted at by Dr Cheng-Chung Fang, MD who examined nearly 10,000 patient records of those who had been hospitalized for a heart attack over a six year period. [Common pain relievers may increase heart attack risk during respiratory infections]
 
As we’ve pointed out a few times in our research, it’s very hard to prove causation. Correlation is not causation, and causation is very difficult to “prove” in medicine.
 
However, these results have moved physicians to reconsider their prescribing habits, and take into consideration more factors when prescribing NSAIDS for acute respiratory infections.
 
And, if I could prescribe, I’d say a good magnesium and a good vitamin E complex with mixed tocopherols and mixed tocotrienols, and no synthetics to keep your blood from forming dangerous clots. Or you could take a look at our article:
Nutrients and Supplements for Preventing and Reversing Cardiovascular Disease for supplements that inhibit platelet aggregation that can form clots. 


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