something we’ve promised our readers for the longest time, but
sadly, not much has really happened with the drug. It is not any
closer to being released than it was in our first reports. This is
one reason we’ve focused on Oleander Soup and
oleander extracts from Brazil mixed
with Cat’s Claw, Pau D’Arco,
and the ABM Mushroom.
We received an
email telling us about another oleander extract called Xenavex,
which we told our readers about in a newsletter, and we also printed
a warning that Xenavex is a cardioglycoside (like digitalis).
received a letter from Paul McLouth, Executive Manager of
ShimodaAtlantic Oncology. He told us that our language was
“extremely misleading and seemingly couched in such a fashion as to
scare potential or existing patients.” He wanted us to know that
cancer patients using Xenavex did not receive any syringes and that
Xenavex was a safe drug.
Here’s what we
found in an article called
Cardiac Glycosides (copyrighted by the American Heart
longer term infusion of plant-derived [cardiac glycosides] (15
µg/kg per day for 18 weeks), at doses that just double
the plasma levels (from 0.3 to 0.7 nmol/L), produced
hypertension and cardiac hypertrophy [abnormal
enlargement of the heart]
Moreover, a growing number of studies suggest that
elevated levels of endogenous cardiac glycosides . . .
may have a primary role in cardiac dysfunction and
even if you are a new patient to these drugs, you might experience
the following side effects:
or yellow vision, confusion, dizziness, mental depression, feeling
of not caring, headache, loss of appetite, seeing or hearing things
that are not there, and/or weakness; diarrhea, loss of appetite,
lower stomach pain, nausea, and/or vomiting; irregular or slow
heartbeat, palpitations (feeling of pounding in the chest), and/or
Xenavex is an
alcohol extract of the Nerium Oleander plant; the amount of
cardioglycosides increases, and the polysaccharides disappear.
When we did not
retract our statements about Xenavex, we received a few threatening
letters from a variety of people who, according to investigative
journalist Tony Isaacs, did not exist; he’s thoroughly investigated
this Paul McLouth and had concluded that this person too does not
Tony wrote us
I have an email
from a now-deceased "patient" of theirs named Patrick who WAS given
the syringe life saving kit - and whose tumors, which had shrunk and
stabilized on Anvirzel, began to grow when “Someone” convinced him
to stop, and then continued to grow when he switched to Xenavex.
The simple fact
is that the ethanolic extraction method used by the Russians only
gets a small amount more oleandrin than the water extraction method,
but loses the vital polysaccharides and other synergistic compounds
that make Anvirzel and the folk remedy version so effective. Over
500 different compounds have been identified in an aqueous solution
of oleander extract, and it is still not fully understood how they
work together. I might add that the "serio neriolini" imported from
Russia was formulated to treat heart conditions with no regards to
cancer or any other cell proliferative disease.
Back to Anvirzel™
Where Anvirzel stands is the
question of the decade. Ozel owns the patent and the trademark,
though they did let it lapse once. There is no funding to continue
Phase II trials. There has been a legal agreement between Ozell and
Phoenix Biotech that “hold each other harmless,” meaning that both
companies can make Anvirzel™.
The problem with an oleander
extract (even though it was determined during Phase I trials to be
safe) is how the FDA looks at it. The following is an FDA abstract
on Oleander Extracts.
of Oleandrin and Oleandrigenin in Oleander Extract by LC/MS and
Walden H. Lee
and Kin S. Chiu, Pacific Regional Laboratory-Southwest, FDA, Los
Angeles, CA 90015
is an ornamental shrub found in the sun belt areas of the United
States. The plant contains "digitalis-like" cardioglycosides that
are highly toxic to animals, including humans. Oleander has been
reported to have therapeutic effects in cell proliferation disease
and a patent exists for the production of an extract. Due to the
unsubstantiated medical claim, the toxicity of the plant and its
potential use as an herbal drug, an identification method for two
toxic components, oleandrin and oleandrigenin, was developed. For
regulatory purposes, the method uses reversed phase liquid
chromatography (LC) with electrospray ionization/mass spectrometry
(MS) and MS/MS detection.
What this boils down to is if a
package is opened that contains Oleander Extract, it will be
confiscated. If it was shipped in the US to a US address, the
shipper can be arrested. Only packages of Anvirzel™ shipped under
the FDA’s own “exception” rules are legal.
No matter how safe we show the
Oleander Extract to be, the FDA is not going to allow anyone to
create a supplement from it, and the ostensible reason is
“unsubstantiated medical claims” while others in the natural
medicine arena say that the FDA is protecting the profits of the
"Everyone should know
that the 'war on cancer' is largely a fraud." Linus Pauling
Ozel’s own research showed that
Nerium Oleander Extract was successful in 70% of cancer patients who
had not done chemotherapy, and 30% successful in cancer patients who
had done chemo therapy. As you’ll see later, mixed with other plant
medicinals, we can improve these success rates even more.
Crandell Addington is the
president of Phoenix Biotech. He was one of the original investors
in Ozel Pharmaceuticals, and still owns a considerable portion of
The Salud Integral clinic in
Honduras was originally built by Ozelle Pharmeceuticals, but Ozelle
ran out of funding and had a falling out among the management and so
Crandell ended up putting together what ultimately became Pheonix
The chief medical advisor to
Phoenix Biotech is MD Anderson's fairly renown Doctor Robert Newman
whose name can be found on many scientific studies, including most
of the ones done on Anvirzel™/oleandrin.
Salud Integral is really the only
place that tested Anvirzel™ thoroughly on cancer patients. They are
releasing it to the US under FDA exception rules (for people who’ve
tried everything or who are considered terminal). In Honduras,
Anvirzel™ has been previously approved for manufacture, sale, and
distribution by their Health Ministry. Anvirzel™ is also approved
for sale and distribution in El Salvador and Guatemala.
Here in the US, Phase I trials
are ended, and here is the summary:
Anvirzel™ is an aqueous extract of the plant Nerium oleander which
has been utilized to treat patients with advanced malignancies. The
current study reports a phase 1 trial to determine the maximum
tolerated dose (MTD) and safety of Anvirzel™ in patients with
advanced, refractory solid tumors. Patients were randomized to
receive this agent by intramuscular injection at doses of 0.1, 0.2,
0.4 ml/m2/day with subsequent patients receiving 0.8 or 1.2
ml/m2/day sequentially. Eighteen patients were enrolled and
completed at least one treatment cycle of three weeks. Most patients
developed mild injection site pain (78%). Other toxicities included
fatigue, nausea, and dyspnea [labored breathing]. Traditional dose
limiting toxicity was not seen, but the MTD was defined by injection
volume as 0.8 ml/m2/day. No objective anti-tumor responses were
seen. Anvirzel™ can be safely administered at doses up to 1.2
ml/m2/day, with the amount administered intramuscularly limited by
volume. The recommended phase II dose level is 0.8 ml/m2/day.
Phase I trials are simply to
determine dosing and safety. As you can see, side effects were
minimal and that they used an injectable form only. These trials are
very short, and one can hardly judge a drug’s prospects in Phase I
trials. Because Anvirzel™ was not administered orally, they could
not use the doses that Dr Ozel had used in his original research
when his patients drank the water extract.
Addington and Pheonix Biotech
have formulated a pill form of oleander extract that is much more
potent than Anvirzel™. It has greater concentrations of the
cardiaglycosides such as oleandrin and oleandrinogen.
Crandell Addington tells us that
it has not yet undergone any USFDA Clinical Trials, but that he
anticipates a Phase I trial soon.
Phoenix Biotech has sunk millions
into researching Anvirzel™ and they have given away, absolutely free
on a case by case basis, a lot of medicine to people dying of
Whether Anvirzel™ ever makes it
to market is open to question: Addington says that their plan is to
get a major pharmaceutical company to buy them out after the
preliminary work, since those are about the only ones who can play
the billion dollar FDA approval game these days. [In our article
Health Care for Dummies, you’ll see how the pharmaceutical
industry raised the bar so high that no one other than the filthy
rich pharmaceutical companies can actually play this game.]
We have just published
Ozel-Vance’s story of Anvirzel™
and her father’s
history of research with the Nerium Oleander Extract. Some of the
investors in the original company have a slightly different take on
Anvirzel’s™ history, with Crandell Addington adding this:
statement about Ozel having the only USFDA approval for use of
Anvirzel as a compassionate use drug is not accurate. It is
unequivocal that Salud Integral imports Anvirzel into the U.S. with
the knowledge of the FDA. The FDA has discretionary authority to
allow importation of unapproved drugs into the U.S. under certain
circumstances. These can be found on the Web.
Oleander continues to work
miracles around the world, and it is also very effective as a skin
cream to remove age spots, warts, moles, and pre-cancerous lesions.
One user informed us that it eliminates gum disease and instantly
stops sore throat whenever he has it.
To paraphrase the folks at MD
Anderson: no one is sure exactly how it works, but Anvirzel™ seems
to have an ability to target and attack bad cells and only bad
cells, and it kills them as well as prevents their replication.
Nerium Oleander extract greatly
improves the immune system, and though I hardly recommend
chemotherapy, taken with chemotherapy, Oleander Extract eliminates
or alleviates all known chemo side effects.
Oleander Extract has been tested,
in limited situations, successfully on cancer, AIDS, lupus, malaria,
hepatitis C, and other viral diseases.
Tony Isaacs forwarded us an email
with a testimonial from his aunt who is caring for his 84 Year old
Uncle with lung cancer. He has been taking both Anvirzel™ and the
We saw the
Oncologist last Friday and got a copy of the CT Scan which was done
This is a quote: "Approximately 20% overall decrease in size of
central mass and associated obstructive pneumonia or atelectasis of
left upper lobe since previous study of January 2006. No new CT
evidence of metastatic disease. No significant pleural effusion. CT
abdomen negative for metastatic disease.
Needless to say, we are ecstatic over this news. Edward does take
Anvirzel and oleander Soup now regularly. We sent a copy of the
report to Dennis so that he can forward it to Honduras. Looks like
the oleander is working wonders. Again, many thanks for all your
Oleander Extract in Africa
A naturopathic physician, Dr Marc
Swanepoel [who should immediately be taken out and cloned] has kept
in touch with Tony Issacs while conducting research in Africa on
AIDS and cancer. I’ll let Marc tell us in his own words what is
ok here and cancer patients as well as HIV patients on the oleander
mix are doing well.
doctor in Cape Town who is using the mix for all his cancer patients
has continued to have good results. The oncologist where he sends
his patients to was so impressed with the results that she is now
using it herself for prevention.
I am nearly
finished with my PhD in Natural Health and I will be starting the
research part of my thesis shortly. I am doing a placebo controlled
double-blind study on the effectiveness of the oleander mix on the
CD4 cell count and viral load of advanced HIV/AIDS patients with a
CD4 count of less than 200. Will keep you posted on the results.
To date, the
only patients that did NOT make it on the oleander mix were three
patients with very advanced cancer that had metastasized to the
liver and who had been on intensive chemo treatments. In my opinion,
the effect of the chemo on the liver and heart eventually led to
failure of those organs. I therefore believe that it is essential
for those kinds of patients to take herbal supplements that enhance
liver function (like milk thistle and dandelion). The Cape Town
doctor puts all his patients on adaptogens (Prime1).
When pressed for more details,
Marc wrote the following:
350 HIV/AIDS patients have used it and about 80 cancer patients on a
regular basis. Of the cancer patients, 5 arrived when they had about
a week to 10 days to live and they were too weak to keep the mix
down. They died without really being able to try the mix. 3 (the
ones I mentioned to you) died of liver and heart failure. All the
others are still alive, some now for nearly three years. One Breast
Cancer patient who was given a few months to live eventually became
the patient of the oncologist who is now also using the mix. She was
declared free of cancer by the oncologist approximately 1 year ago
and is still doing well. Others used it for a few months until their
cancers were gone and we have not heard from them again. One patient
with a festering hole of 1cm diameter on his nose (about half a cm
deep) have been using it for three months after doctors were unable
to cure the tumour with radiation. The hole is now half the size and
not festering anymore. It should be healed in about 3 - 6 months.
The doctor in Cape Town whose own wife had metastasized cancer to
the bones, is now cancer free. She has been on overseas trips and
lives a normal life.
Unfortunately, I do not have time to keep track of all the patients.
They just collect the mix from me and phone me from time to time to
say that they are doing well. It also seems to help for asthma, male
impotence and diabetes. One advanced MS patient has now used it for
2 months and is reporting that it seems to help for the pain in her
legs. All the distribution is happening by word of mouth and I don't
advertise at all. I have had orders from the UK from people who had
heard about the successes in South Africa. A documentary maker there
was filming the progress of his wife on a weekly basis but,
unfortunately, she was one of the liver complications. He still
believes very firmly that the mix gave his wife an extra 5 months of
high quality life.
In our Alternative Cancer
Therapies, we list a product from Brazil called OPC, which is an
admixture of Oleander Extract, Cat’s Claw, Pau D’Arco, and ABM
Mushrooms. It was Marc who helped the people in Brazil create this
concoction, but sadly you either can’t get a hold of these people (Takesun,
Inc) or if you do it costs you $299.00 for a bottle of 500ml of the
OPC while an American distributor sells it for $345.00/bottle.
Marc has told us that he has
about 100 bottles left and will send them to anyone (only two per
customer since the smaller the package the better to slip by the
FDA) for a total of $99.00 per bottle. If the FDA confiscates them,
it’s not his problem. Just know that ordering one more would be
still cheaper than buying it from Brazil even if you could get a
hold of the people.
Marc has also intimated that he’s
not so keen on the ABM Mushroom anymore (though he does admit that
of all the mushrooms, the ABM is the best of the healers), since
he’s discovered a plant in Africa called the Sutherlandia Frutescens.
The combination of Oleander and Sutherlandia is the basis of his PhD
thesis. The Sutherlandia has a long history of medicinal uses, is
readily available, and from his own experience, works better with
Oleander Extract than the ABM Mushroom.
When he’s run out of his current
supply of OPC and gets his production facilities up and running,
he’ll be supplying Sutherlandia OPC to the world from Africa.
Hopefully, this will all come about sometime in April.
You can get a hold of Marc at
this email address:
* * *
For those of you who would like more information on
the African "cancer bush, the Sutherlandia Frutescens that Marc
mentioned above, go to